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UCT Silane (DETA) cited in bio-physiological research paper

Wednesday, June 07th, 2017

UCT is widely recognized as the premier manufacturer of specialty chemicals by researchers working in the area of biological analysis and modeling. This is exemplified by a paper published in Biomaterials by X.Guo et al.,  ((2017) 122 179-187).  In their study,  they report the de novo induction of human intrafusal skeletal muscle fibers from satellite cells and their synaptic connection with human stem cell-derived sensory neurons in a defined in vitro system. As an integral part of the study, process microscope coverslips were coated with UCT’s silane trimethoxysilylpropyldiethylenetri-amine (DETA, T2910KG) and were used to produce a film by the reaction of the cleaned surfaces with a 0.1% (v/v) mixture of the organosilane in freshly distilled toluene. This film was employed to study the induction of intrafusal fibers which were characterized by morphology and fiber-type specific transcription factor expression using phase microscopy and immunocytochemistry.

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