Founded in 1986 in Horsham, PA, United Chemical Technologies, Inc. (UCT, Inc.) has grown from a manufacturer of solid phase extraction sorbents into a major competitor in the fields of specialty chemicals, chromatographic media and sample preparation products. UCT began with a novel technological idea for solid phase extraction (SPE): bond two different functional groups to a solid support material in order create phases that are capable of extracting samples based on different chemical principles. The first product was our CLEAN SCREEN® DAU. This product incorporated an ion exchange functionality with a hydrophobic alkyl chain. This product was quickly adopted in analytical labs and is now the most widely used SPE material in the clinical and forensic industry for the clean extraction of biological matrices.
UCT Specialty Chemical Cited in Biomolecular Study
In a recent paper published in ACS Biomaterials Science and Engineering by Darin Edwards et al., (DOI: 10.1021/acsbiomaterials.7b00596), UCT’s organosilane DETA (N-1 [3-(trimethoxysilyl) propyl]-diethylenetriamine, T2910KG) was used to form a monolayer on a microslide by the reaction of the cleaned surface with a 0.1% (v/v) mixture of the organosilane in freshly distilled toluene. These slides were used to study biological cultures involving N-Methyl-D-aspartic acid (NMDA) and α-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic Acid (AMPA) channel expression. The cultures were exposed to synaptic transmission antagonists against NMDA and AMPA channels which revealed significantly different receptor profiles of adult and embryonic networks in vitro.