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UCT Silane Cited in Plasmon Research Study

Ultrasensitive and selective detection and quantification of dopamine (DA) plays a key role in monitoring neurodegenerative diseases and the detection limit reported is typically in the lower nanomolar range. Pushing the detection limit to picomolar (pM) or lower for this particular target to cover the physiological levels (< 130 pM) is significant. In the following article, DA DNA aptamer (DAAPT) gold nanoparticle (AuNP) conjugate is utilized to enhance the surface plasmon resonance (SPR) signal, which enables to detect and quantify DA in the femtomolar (200 fM) to pM range.

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UCT’s DETA cited in Stem Cell Research Study

In a recent paper authored by Navaneetha Santhanam et al, published in Biomaterials ((2018) 166 64-78), UCT’s specialty chemical 3-trimethoxysilyl propyl diethylenetriamine (DETA), an amine-terminated alkylsilane, was employed to promote cell adhesion. This study was designed to develop and evaluate a prototype of a drug-screening platform for neuromuscular junctions at different modes of operation: presynaptic and/or postsynaptic

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DAU Sorbent cited in Equine Toxicology Study

In a recent study published in Drug Testing and Analysis (DOI: 10.1002/dta.2378), authored by Heather K. Knych et al, UCT’s Clean Screen® DAU was employed to extract grapiprant following oral administration to exercised thoroughbred horses. Grapiprant is a newly approved non‐ cyclooxygenase inhibiting non‐steroidal anti‐inflammatory drug that has demonstrated efficacy and safety in other species. As long‐term use of these drugs can adversely impact the health of the horse, anti‐inflammatories with a more favorable safety profile are warranted.

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UCT Specialty Chemical cited in Mechanobiology Study

In a recent article published in Lab on a Chip, authors Donghee Lee et al., (DOI: 10.1039/C8LC00320C), used UCT’s specialty chemical (Tridecafluoro-1, 1, 2, 2-Tetrahydrooctyl)-1- Trichlorosilane (T2492-KG) in a mold-making process. This involved the production of a microfluidic cell compression device that improved a microfluidic device proposed previously by equipping it with an array of cell compression units. The device contained a 5×5 array of alginate-chondrocyte constructs. This microfluidic cell was employed to investigate human cartilage cells. T2492-KG played an integral part of this procedure.

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UCT Derivatizing Reagent cited in Forensic Anthropology Study

In a recent study, authored by Susan Luong et al., (Forensic Science International ((2018), 285 93-104)) UCT’s derivatizing reagent O-Bis(trimethylsilytrifluoroacetamide) containing 1% trimethylchlorosilane (BSTFA (1% TMCS)) was employed to assist with the gas chromatographic-mass spectrometric (GC-MS) analysis of a cadaveric break down product. In this research, a human cadaver was placed on the surface of a designated plot at the Australian Facility for Taphonomic Experimental Research (AFTER), the only human decomposition facility in Australia. The natural process of decomposition was allowed to progress over fourteen days during the summer.

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UCT Specialty Chemicals Cited in Cancer Study Article

In a recent paper authored by Xiaoying Wang published in Talanta ((2018) 187 179-187), UCT’s specialty chemicals Tetraethylorthosilicate (TEOS) and trimethoxysilylpropy-diethylenetriamine (DETA) were employed in the process to produce an electrochemiluminescence (ECL) biosensor for detection of CdkN2A/p16 anti-oncogene based on functional electrospun nanofibers and core-shell luminescent composite nanoparticles.

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UCT Silane Cited in Clinical Microbiology Article

In a recent paper authored by Wanyuan Ao et al., published in Journal of Clinical Microbiology (doi.org/10 .1128/JCM.00982-17), UCT’s polymer amine-functional T-structure polydimethylsiloxane ([TSPS] was used in the manufacturing process to coat crystalline silicon wafers in which curing took place at 150°C for 24 hours. The crystalline silicon chip is integral to the analytical process.

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UCT Silane Cited in Organ-On-Chip Article

Organ-on-chip platforms aim to improve preclinical models for organ-level responses to novel drug compounds. Heart-on-a-chip assays in particular require tissue engineering techniques that rely on labor-intensive photolithographic fabrication or resolution-limited 3D printing of micro-patterned substrates, which limits turnover and flexibility of prototyping. In a recent paper authored by Janna C. Nawroth et al., published in Biofabrication ( Biofabrication ((2018) 10 025004), UCT’s silane chemicals were used for soft lithography fabrication of stamps for micro-molding hydrogels. The authors developed a rapid and automated method for large scale on-demand micro-patterning of gelatin hydrogels for organ-on-chip applications using a novel biocompatible laser-etching approach.

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UCT Specialty Chemical cited in Monolithic Chromatography Study

Monolithic materials are versatile adsorbents widely employed in separation science, sample preparation and as supports for flow through applications (e.g. heterogeneous catalysis, ion-exchange, solid-phase extraction, etc). Interest around their preparation and applications has been steadily on the rise. In a recent paper published in Journal of Chromatography A ((2017) 498 46-55) by Patrizia Simonea et al., UCT’s specialty chemical N-trimethoxysilylpropyl)-polyethylenimine was employed in the production of capillary methacrylate-based monoliths. This process was executed by grafting from/to ƴ -ray polymerization on a tentacle-type reactive surface for the liquid chromatographic separations of small molecules and intact proteins.

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UCT Specialty Chemical Cited in Biomolecular Study

In a recent paper published in ACS Biomaterials Science and Engineering by Darin Edwards et al., (DOI: 10.1021/acsbiomaterials.7b00596), UCT’s organosilane DETA (N-1 [3-(trimethoxysilyl) propyl]-diethylenetriamine, T2910KG) was used to form a monolayer on a microslide by the reaction of the cleaned surface with a 0.1% (v/v) mixture of the organosilane in freshly distilled toluene. These slides were used to study biological cultures involving N-Methyl-D-aspartic acid (NMDA) and α-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic Acid (AMPA) channel expression. The cultures were exposed to synaptic transmission antagonists against NMDA and AMPA channels which revealed significantly different receptor profiles of adult and embryonic networks in vitro.

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UCT Silane Cited in Biomolecular Engineering Paper

In a paper authored by E. L. Jackson-Holmes et al., in Lab on a Chip ((2017), 17, 3634), UCT’s silane, tridecafluoro-1,1,2,2- tetrahydrooctyl-1-trichlorosilane, was employed in an integral role in a vapour form to produce a polydimethylsilane (PDMS) master in a procedure in which a microfluidic platform was developed for culture, longitudinal monitoring, and phenotypic analysis of individual stem cell aggregates. This novel platform uses a hydrodynamic loading principle to capture pre-formed stem cell aggregates in independent traps. 

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UCT Silane Cited in Cellular Research Article

In a recent article published in Lab on Chip by E.L. Jackson-Holmes et al., (DOI: 10.1039/C7LC00763A), tridecafluoro-1,1,2,2-tetrahydrooctyl-1-trichlorosilane from UCT was integral in the production of a mold to perform their intended research. In the procedure, a master mold was fabricated by standard UV photolithography with the negative photoresist to create three layers of respective heights 200 μm, 100 μm, and 200 μm. In making the polydimethylsilane (PDMS) molding, the master was treated with the UCT silane vapor to allow release of the PDMS. These three-dimensional pluripotent stem cell (PSC) cultures have the ability to undergo differentiation, self-organization, and morphogenesis to yield complex, in vitro tissue models that recapitulate key elements of native tissues.  For more information on UCT specialty chemicals visit https://specialties.unitedchem.com/

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UCT Silane (TSPS) cited in Microbiology Article

Numerous polymerase-chain-reaction (PCR) and isothermal amplification methods employed currently in molecular diagnostic assays have been developed, significantly improving assay sensitivity and specificity as well as shortening overall time. In spite of this objective, nucleic acid target amplification continues to present challenges for dealing with “false-positive” results due to environmental or reagent contaminants introduced during the testing process. This has been addressed in a recent article authored by Wanyuan Ao et al., published in PLoS ONE 12(2): e0171915 in which UCT silane amine-functional T-structure polydimethylsiloxane (TSPS) was described in the production of crystalline silicon wafers. In this paper, the authors describe a strategy that can distinguish between staphylococcus species truly present in a clinical sample from contaminating staphylococcus species introduced during the testing process.

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UCT Silane (DETA) cited in bio-physiological research paper

UCT is widely recognized as the premier manufacturer of specialty chemicals by researchers working in the area of biological analysis and modeling. This is exemplified by a paper published in Biomaterials by X.Guo et al.,  ((2017) 122 179-187).  In their study,  they report the de novo induction of human intrafusal skeletal muscle fibers from satellite cells and their synaptic connection with human stem cell-derived sensory neurons in a defined in vitro system. As an integral part of the study, process microscope coverslips were coated with UCT’s silane trimethoxysilylpropyldiethylenetri-amine (DETA, T2910KG) and were used to produce a film by the reaction of the cleaned surfaces with a 0.1% (v/v) mixture of the organosilane in freshly distilled toluene. This film was employed to study the induction of intrafusal fibers which were characterized by morphology and fiber-type specific transcription factor expression using phase microscopy and immunocytochemistry.

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UCT Silane Cited in Novel Separations Article

UCT is world renowned as the premier manufacturer of the finest specialty chemicals including silanes and siloxanes. Researchers in the field of separation science looking to advance the boundaries require the finest of materials for their studies. In a recent paper authored by Patrizia Simone et al., (Journal of Chromatography A ((2017) 1498, 46-55) a UCT silane (N-trimethoxysilylpropyl)-polyethylenimine was utilized as an important reagent in the production of a monolith for separations of small molecules and intact proteins.

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UCT Specialty Chemical (TSPS) cited in Clinical Chemistry Article

UCT is known around the world as the premier manufacturer of the finest specialty chemicals used in the field of clinical research. In a recent paper published in Plos One (12(2): e0171915. doi:10.1371/journal.pone.0171915) by R.Jension et al., “A novel approach to eliminate detection of contaminating Staphylococcal species introduced during clinical testing”, UCT’s T-structure polydimethylsiloxane (TSPS) was used to coat crystalline wafers used in the procedure. This chip utilizes TSPS as a specialty chemical integral to the process. 

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Visit UCT at the 3rd Annual 2017 Emerald Conference February 2nd-3rd

UCT is proud to support Emerald Scientific’s 2017 annual conference which is devoted to the deep exploration and discussion of the science of cannabis, including analytical testing, extraction and infusion sciences, cultivation sciences, clinical applications, inter-lab comparison and proficiency testing, state regulations, industry standardization, and more.  Please join us all week at BOOTH 132 to learn more about our latest product offerings including QuEChERS products and well-plates geared towards the analysis of cannabis and edible products, Selectra® HPLC columns, GC liners, Selectra-Sil® Dervatizing Reagents, and Ultra Flash® Flash Chromatography Purification offerings. 

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UCT to Attend 2017 MSACL in Palm Springs!

UCT is excited to participate in the 9th Annual MSACL Conference & Exhibit. Stop by BOOTH 1 to learn about all our latest product offerings and collaborations, including our HPLC columns, QuEChERS products geared towards the analysis of cannabis and edible products, Abalonase®/ Abalonase®+ Purified Beta Glucuronidase, as well as our full line of sample preparation products, reagents, and accessories.

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UCT Silane cited in Biomaterials Paper

UCT Inc., is highly regarded by researchers in the area of biomechanical analysis for the manufacture and production of the very finest specialty chemicals including silanes and siloxanes. In a new paper by Prof. J.Hickman et al., NanoScience Technology Center, University of Central Florida (Journal of Biomaterials (10.1016/j.biomaterials.2017.01.005)), UCT’s specialty chemical trimethoxysilylpropyldiethylenetriamine (DETA, T2910KG) was employed to produce a film on microscope slides. These slides were then used for the induction of human intrafusal skeletal muscle fibers from satellite cells and their synaptic connection with human stem cell-derived sensory neurons in a defined in vitro system.

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UCT Silanization Reagent Cited in Capillary Monolith Paper

UCT Inc., is known around the world for the manufacturing of the very finest in specialty chemicals including (N-trimethoxysilylpropyl)-polyethylenimine. These compounds are regularly employed by researchers in fields such as the production of methacrylate-based monoliths for highly efficient separations. In a recent paper published in Journal of Chromatography A by P. Simone et al., (Sapienza Università di Roma, Italy (http://dx.doi.org/10.1016/j.chroma.2016.11.039)) capillary methacrylate-based monoliths were prepared for the high performance liquid chromatography (HPLC) separation of both small molecules and large biomolecules. An efficient grafting from/to synthetic approach was adopted introducing a network of activated sites in the inner wall surface using the new silanization agent (N-trimethoxysilylpropyl)-polyethylenimine obtained from UCT.

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Thanksgiving Holiday

UCT will be closed for the holidays on November 24th-25th. Normal business hours will resume on Monday, November 28th. We wish you the happiness of good friends, the joy of a happy family, and the wonder of the holiday season. Have a memorable Thanksgiving!

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Happy Veteran's Day to our honorable service men and women from all of us at UCT!

As we express our gratitude, we must never forget that the highest appreciation is not to utter words, but to live by them - President John F. Kennedy

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UCT Silane used in Cellular Modeling

In the field of bio-mechanical research, scientists working in the field of cellular modeling require the finest of specialty chemicals in order to produce world class studies. UCT Inc., is known around world as a premier manufacturer of Silanes and Siloxanes.

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UCT Silane Cited in Microfluidic Article

UCT has long been recognized for the support of research bio-pharmaceutical scientists working on micro-fluidics through its Specialty Chemical line producing the finest of silanes in the market place. In a recent paper by Kim et al., based at Texas A&M University, USA (Micromachines (2016), 7, 114; doi:10.3390/mi7070114) used UCT's tridecafluoro-1,1,2,2-tetrahydrooctyl trichlorosilane in their procedure to produce a microfluidic unit.

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Join UCT at CANNCON 2016!

UCT is proud to support Canncon’s 2016 annual conference which unites cannabis industry experts, instrument manufacturers, testing labs, research scientists, medical practitioners, policy makers and interested novices. Please join us all week at  BOOTH 100 and several other educational platforms to learn more about our latest product offerings

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UCT Siloxane cited in Split Ring Resonator Research

UCT's Petrarch Specialty chemical line is world renowned for being of the finest quality and employed by scientists working at the cutting edge of electronic engineering research.In a paper published by Fan Zhou et al (Northeastern University) in Optical Express ((2016), 24: 6367) a detailed study was reported into Split ring resonators which employed the use of UCT product poly[(mercaptopropy)methylsiloxane] (PMMS) to fabricate the soft stamps. Browse UCT's selection of high quality specialty chemicals today!

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UCT Silane Cited in Robotic Paper
In the field of human animatronics, the use of specialty chemicals must be of the highest quality due to the degree of precision for the electronics and the engineering that is employed. UCT Inc., is recognized around the world by scientists working in the field of miniaturization of robotics and rightly turn to UCT as the premier manufacturer of the finest specialty silanes. Continue Reading
Fourth of July Holiday Wishes and Closure Notice

Please note that UCT will be closed on Monday July 4th, 2016 in observance of Independence Day. We will reopen Tuesday, July 5th at 8 am EST.

We wish all of our clients a very happy and safe 4th of July holiday.

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UCT Specialty Chemical Cited in Cardiovascular Study

UCT is world renowned for its support of biological research through its specialty chemicals, and in a recent study published in PLOS ONE by S.Chen et al., ( http://dx.doi.org/10.1371/journal.pone.0155681), UCT’s silane  (tridecafluoro-1, 1, 2, 2-tetrahydrooctyl-1 tri-chlorosilane) was employed in the 3D printing process for synthetic replacements for large-diameter blood vessels. 

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Petrarch® silane used in the manufacture of a custom microchip used in the study of CNS axon growth

In a recent publication titled A microchip for quantitative analysis of CNS axon growth under localized biomolecular treatments, Journal of Neuroscience Methods,221, (2014) 166-174, (doi:10.1016/j.jneumeth.2013.09.018) tridecafluoro-1, 1, 2, 2- tetrahydrooctytrichlorosilane (T2492) from UCT Specialties, LLC was used to vapor coat cast molded poly(methylmethacrylate) and PDMS parts.

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UCT Receives ISO Certification

UCT has consistently produced high quality and reproducible organosilicon products.  That commitment was ensured through rigorous manufacturing and quality assurance programs.  Today we are pleased to announce that the system’s upon which our quality is based have been rewarded.

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Petrarch® Silanes from UCT Specialties Used for QuEChERS Products Research Investigation

In a recently published paper, Chromatographia, DOI 10.1007/s10337-014-2726-5, researchers at the University of Campinas, Sao Paulo, Brazil compared different sorbents in the QuEChERS technique.  The article is titled, “Comparison of Different Sorbents in the QuEChERS Method for the Determination of Pesticide Residues in Strawberries by LC–MS/MS.”

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Petrarch® Specialties Bio-Conext Material Used in Isolating Strains of Con A and E. Coli

In the article ‘Dye-Doped Silica Nanoparticles as Efficient Labels for Glycans’ published in the Journal for Chemical Communications (supplementary information),  The Royal Society of Chemistry2011, DOI: 10.1039/C0CC05299J. UCT Specialties Product, PSX1050  -  (3-Trimethoxysilyl)butylaldehyde  - was used to isolate strains of Con A and E.Coli on lectin microarrays.

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UCT Specialties Petrarch® Silanes and crosslinkers used in the study of the dynamic response of transiently trapped entanglements in polymer networks

In a paper recently published, Polymer, 55 (2014) 1061 – 1069, the Dynamic Response of transiently trapped entanglements in polymer networks was studied.

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UCT Specialties Product A0700 (N-(2-Aminoethyl)-3-aminopropyltrimethoxysilane) Used as Coating on Glass Coverslips to Aid in Growth of Mouse ES Cells

In an article published in The Journal of Biological Chemistry, VOL. 288, NO. 47, pp 34168 – 34180, November 22, 2013, Simandlova, et.al., UCT Specialties Product A0700, N-(2-aminoethyl)-3-aminopropyltrimethoxysilane,  was used as a coating on the glass coverslips upon which mouse ES cells were grown and examined.  

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Petrarch® Chemicals Tricholosilane used as a release agent in the development of a microfluidic chip

Kamruzzaman, et.al., developed a microfluidic chip that allowed the detection of L-phenylalanine in pharmaceutical and soft drink products.  This work was reported inFood Chemistry, 135, (2012) 57 – 62.

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